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The antihypertensive action is due to a decrease in cardiac output and synthesis of renin inhibition of renin — angiotensin system and the central nervous system. The hypotensive effect develops rapidly Sad decreases after 15 minutes, maximum ; 2 hours and lasts for 6 hours; while taking metoprolol succinate ; clinical effects of beta blockade 1 — adrenoceptor saved 24 hours Dad slowly changing: Antianginal effect is the consequence of reducing the frequency and strength of heart contractions, energy consumption and myocardial oxygen demand.

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The test results of dominant lethal mutations in the mouse, the study of somatic cells chromosomes, test abnormalities somatic cell nuclei in interphase and al. In rats receiving doses in excess of 55. The volume of distribution ; 5.

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Contraindications Hypersensitivity, AV buy Online Generic Metoprolol II and III degree sinoatrial block, acute or chronic in the stage of decompensation, heart failure, sick sinus syndrome, severe sinus bradycardia heart rate less than 60 beats. Application of x33902jk.beget.tech therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding. Side effects of substance metoprolol From the nervous system and sensory organs: From the cardio — vascular system and blood blood, hemostasis: From the digestive tract: From the respiratory system: Antiarrhythmic and anesthetic agents increase the buy Online Generic Metoprolol of bradycardia, arrhythmia, hypotension.

Preparations potentiate digitalis slow AV conduction. Beta — agonists, aminophylline, cocaine, estrogens, indomethacin, and other NSAIDs weaken the antihypertensive effect. Enhances and prolongs the effect of muscle relaxants antidepolyarizuyuschih.

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Aged patients are recommended to start from 50 mg daily dose. Precautions Avoid drinking alcohol as its interaction with Lopressor increases drowsiness and dizziness. Contraindications Hypersensitivity to the components of the medication, acute or chronic buy Online Generic Metoprolol failure, arterial cheap Aggrenox congestive buy Online Generic Metoprolol failure, asthma or other breathing problems, diabetes, disorders of perepherial blood circulation, pregnancy, breast-feeding, depression, Buy Online Generic Metoprolol, liver or kidney disease, a thyroid disorder, or myasthenia gravis.

Possible side effect At the background of common tolerance to the medication among side effects are noticed abdominal cramps, fatigue, insomnia, nausea, depression, memory loss, fever, impotence, lightheadedness, slow heart rate, low blood pressure, cold extremities, sore throat, diarrhea, constipation, and shortness of breath or wheezing. Lopressor also is able to mask the early symptoms of low blood sugar and should be used with caution in patients suffering from diabetes.

Missed dose Take the forgotten dose as soon as you remember. If your next dose is less than 4 hours away, skip it and return to your schedule. Do not try to compensate a missed dose by taking an extra one.

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